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A Phase I Study of Intra-Arterial Yttrium-90 Radioembolization for Unresectable Pancreatic Cancer
Sponsor: National Medical Research Radiological Centre of the Ministry of Health of Russia
Summary
This clinical study aims to evaluate the safety and tolerability of intra-arterial Yttrium-90 (90Y) glass microspheres in patients with unresectable pancreatic adenocarcinoma. The study will assess radiation dose distribution, adverse effects, and preliminary efficacy following selective arterial radioembolization.
Official title: Selective Intra-Arterial Yttrium-90 Radioembolization for the Treatment of Unresectable Pancreatic Adenocarcinoma: A Phase I Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2025-02-11
Completion Date
2028-03
Last Updated
2026-10-27
Healthy Volunteers
No
Conditions
Interventions
Transarterial Radioembolization
Selective intra-arterial infusion of Yttrium-90 (90Y) glass microspheres into the pancreatic tumor via catheterization of tumor-feeding arteries. The intervention involves pre-treatment dosimetry planning using 99mTc-MAA SPECT/CT, followed by sequential dose escalation of 90Y activity corresponding to absorbed doses. Post-therapy imaging (SPECT/CT) will be performed to assess microsphere distribution and radiation dosimetry.
Locations (1)
Medical Radiological Research Center named after A.F. Tsyb (MRRC) - National Medical Research Center of Radiology
Obninsk, Russia