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Nutrition and Swelling
Sponsor: University of California, San Francisco
Summary
This study is looking at whether taking a nutritional supplement before and after knee replacement surgery affects normal recovery. The supplement is Xcelerated Recovery (XR), an over-the-counter supplement made with essential amino acids (EAAs), which are building blocks of protein that the body cannot make on its own. Participants aged 65 and older with planned knee replacement surgery, and signs of nutritional risk or reduced muscle strength on short screening questionnaires, will be invited to join. Participants are assigned by chance to one of two groups. One group receives usual care plus the XR supplement, taken twice a day starting 7 days before surgery and continuing for 14 days after surgery. The other group receives usual care without the supplement. Everyone in the study wears a small temporary skin sensor (similar to a temporary tattoo) on the knee and uses a smartphone app to take scans that measure knee size. Participants also have in-person visits before surgery and 2 weeks and 1 month after surgery. The main goal is to measure how knee and leg size (circumference) changes after surgery in each group. Researchers will also look at muscle strength, knee movement, walking and mobility tests, and reported pain. This study is not testing the supplement as a treatment for any disease or medical condition. The results may help researchers better understand how nutrition relates to normal recovery after knee replacement surgery.
Official title: Impact of Perioperative Nutritional Supplementation on Limb Circumference and Functional Recovery Following Elective Total Knee Arthroplasty: A Prospective Study
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2027-01-01
Completion Date
2027-05-01
Last Updated
2026-10-28
Healthy Volunteers
Yes
Interventions
Xcelerated Recovery Nutritional Supplement
Xcelerated Recovery (XR) is a commercially available, EAA-based multi-ingredient nutritional supplement. Participants assigned to the intervention arm will dissolve the full XR supplement in water and consume it twice daily. Each serving contains 19.2 g of essential amino acids, providing 38.4 g of essential amino acids per day. Supplementation will begin 7 days before total knee arthroplasty and continue through 14 days after surgery. XR is being evaluated for its association with measures of normal physiological recovery following surgery, including tissue fluid balance assessed through changes in limb circumference and measures of physical function.
Locations (1)
UCSF Medical Center at Mount Zion
San Francisco, California, United States