Clinical Research Directory

Inclusion Criteria: * Read and speak English * At least 21 years old * Established cigarette smoker, defined as having smoked at least 100 lifetime cigarettes and smoking at least 5 cigarettes per day for at least the past year, and have a baseline expired carbon monoxide (eCO) of 7ppm or higher at visit 1 * Willing to provide informed consent and abstain from all tobacco, nicotine, and marijuana use for at least 12 hours prior to study visits * Willing to attend all study visits and use study ONPs * Owns a smartphone and is able to receive short message service (SMS) text messages with embedded survey links for daily diary surveys * Willing to provide a urine sample * Willing to provide blood samples during the study Exclusion Criteria: * Unstable or significant psychiatric conditions; past and stable conditions will be allowed * History of cardiac event or distress within the past 3 months * History of uncontrolled blood pressure or shortness of breath in the past 3 months * Currently experiencing problems with irregular heartbeat or abnormal heart rhythm that requires medication * Currently pregnant, planning to become pregnant, or breastfeeding. Pregnancy status will be verified with urine pregnancy testing before clinic visits when applicable * Engaged in a quit smoking attempt in the prior two weeks * Currently engaging in a tobacco quit attempt, interested in quitting all tobacco, or planning to quit all tobacco in the next 2 months * Oral health issues that would affect use of an ONP in the upper or lower lip for 30 minutes * History of weekly ONP use for 3 months or longer * Any ONP use in the past 3 months * History of problematic blood draws