Clinical Research Directory

Inclusion Criteria: * Age 18 years or older at the time of inclusion * Diagnosis of head and neck cancer (histological, cytological or imaging confirmation), including the following sites: oral cavity, oropharynx, hypopharynx, larynx, nasopharynx, nasal cavity and paranasal sinuses * Indication for curative-intent external beam radiotherapy (exclusive or adjuvant), with or without concomitant chemotherapy, exposing the cervical skin * Possibility of starting preventive photobiomodulation (PBM) from the start of radiotherapy according to the standardized protocol (3 sessions/week, 3 J/cm2) * Affiliated with or beneficiary of a social security scheme * Free, informed and express written consent obtained after provision of an information sheet Exclusion Criteria: * Inability to receive PBM due to a contraindication, patient refusal, or radiotherapy duration of less than two weeks * Previous radiotherapy to the cervico-facial region * Uncontrolled or active dermatological condition in the area to be irradiated likely to interfere with the assessment of skin toxicity (psoriasis, eczema, cutaneous lupus, etc.) * Ongoing photosensitizing treatment that cannot be interrupted or replaced during radiotherapy * Severe immunosuppression, defined in particular as HIV infection at the AIDS stage, long-term immunosuppressive treatment, or history of organ transplantation * Concurrent participation in another therapeutic trial likely to affect the occurrence or severity of skin toxicity * Person under legal protection (guardianship, curatorship or safeguard of justice) * Pregnant or breastfeeding woman * Patient refusal to participate in the study