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Dual-Energy Lattice-Tip Assisted Marshall-Plan Strategy in Redo Persistent Atrial Fibrillation Ablation
Sponsor: Karolinska University Hospital
Summary
This clinical trial will assess the efficacy and safety of a Marshall plan-based ablation strategy without ethanol infusion into the vein of Marshall in patients with persistent atrial fibrillation undergoing repeat ablation with a dual-energy lattice-tip catheter. Eligible participants will be randomized to receive either pulmonary vein re-isolation alone or pulmonary vein re-isolation plus the Marshall plan-based strategy. Patients who are found to have all pulmonary veins already isolated at the time of the procedure, or who are not suitable candidates for the Marshall plan-based approach, will be included in a separate observational cohort.
Official title: Dual-Energy Lattice-Tip Assisted "MArshall-Plan" Strategy Versus Pulmonary Vein Re-Isolation Alone in Redo Persistent Atrial Fibrillation: A Randomized Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
234
Start Date
2027-01
Completion Date
2030-03
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Interventions
Marshall Plan-Based Ablation Strategy
Pulmonary vein re-isolation plus posterior mitral isthmus, roof, and cavotricuspid isthmus linear ablation using a dual-energy lattice-tip catheter without ethanol infusion into the vein of Marshall.
PV re-isolation only
Pulmonary vein re-isolation only using a dual-energy lattice-tip catheter.
Additional Left Atrial Ablation
Additional left atrial ablation performed according to the scar distribution
Locations (1)
Karolinska University Hospital
Stockholm, Sweden