Clinical Research Directory

Inclusion Criteria: Adolescents aged 10-18 years with a confirmed diagnosis of idiopathic scoliosis (Cobb angle ≥10°). No clinical evidence of acute or chronic infection or significant systemic inflammation. No recent infection within the preceding three months. No history of gastrointestinal disease or recent antibiotic/probiotic use. No previous scoliosis surgery. Voluntary participation with appropriate informed consent. Exclusion Criteria: Congenital, neuromuscular, or syndromic scoliosis. Inflammatory bowel disease, celiac disease, autoimmune or other chronic inflammatory disorders, rheumatological disease, or malignancy. Family history of inflammatory bowel disease or celiac disease. Recent gastrointestinal symptoms, including diarrhea, gastrointestinal bleeding, unexplained abdominal pain, or weight loss. Infection within the preceding three months. Use of corticosteroids, NSAIDs, or immunosuppressive medications within the preceding three months. Pregnancy.