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Hypofractionated Radiotherapy With Magnetic Resonance Imaging-Guided Focal Boost and Pelvic Irradiation in High-Risk Prostate Cancer
Sponsor: Haukeland University Hospital
Summary
This study evaluated long-term disease control and side effects of a moderately hypofractionated radiotherapy protocol for men with high-risk prostate cancer. The protocol combined three strategies in one course of 25 treatments: a higher dose (focal boost) to the tumor seen on magnetic resonance imaging (MRI), a reduced dose to the uninvolved parts of the prostate, and elective irradiation of the pelvic lymph nodes, together with hormone therapy. Patients were included at Haukeland University Hospital, Bergen, Norway, from 2014 to 2017, with outcomes evaluated up to 10 years after treatment.
Official title: Dose-Escalated Image-Guided Radiotherapy (IGRT) With Magnetic Resonance Imaging (MRI)-Based Target Definition for Locally and Regionally Advanced Prostate Cancer: A Phase II Study
Key Details
Gender
MALE
Age Range
Any - Any
Study Type
INTERVENTIONAL
Enrollment
191
Start Date
2014-02-24
Completion Date
2025-10-01
Last Updated
2026-10-30
Healthy Volunteers
No
Interventions
Hypofractionated IMRT with focal simultaneous integrated boost and elective pelvic irradiation
Image-guided IMRT in 25 fractions: 2.9 Gy/fraction (72.5 Gy) to the MRI-defined tumour, 2.4 Gy/fraction (60 Gy) to the uninvolved prostate and seminal vesicles, and 2.0 Gy/fraction (50 Gy) to the elective pelvic lymph nodes, with a boost of 2.4 Gy/fraction (60 Gy) to involved lymph nodes in node-positive patients.
Androgen Deprivation Therapy (ADT)
Androgen deprivation therapy started approximately 3 months before radiotherapy: an luteinizing hormone-releasing hormone (LHRH) analogue with at least 4 weeks of antiandrogen, or alternatively an LHRH antagonist. Planned duration 18 months if clinically tolerated. Antiandrogen monotherapy was an option in case of poor tolerance of the LHRH analogue.
Locations (1)
Haukeland University Hospital
Bergen, Vestland, Norway