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Effects of Bolus Versus Infusion Ketamine During Laparoscopic Cholecystectomy
Sponsor: Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Summary
This prospective, randomized, controlled study evaluated the effects of different ketamine administration strategies in adult patients undergoing elective laparoscopic cholecystectomy under general anesthesia. Participants were randomized into three groups: bolus ketamine, continuous ketamine infusion, or control without ketamine. The study investigated the effects of these strategies on optic nerve sheath diameter measured by ultrasonography as a surrogate marker of intracranial pressure, intraoperative sevoflurane consumption, and postoperative pain and analgesic requirements.
Official title: THE EFFECT OF ADDING KETAMINE BY BOLUS OR INFUSION TO ANESTHESIA MAINTENANCE IN CASE OF LAPAROSCOPIC CHOLECYSTECTOMİES ON İNTRACRANİAL PRESSURE, SEVOFLURAN CONSUMPTION AND POSTOPERATIVE ANALGESIS, RANDOMIZED CONTROLLED STUDY
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
102
Start Date
2021-12-01
Completion Date
2022-12-01
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
ketamine bolus
Ketamine 0.25 mg/kg was administered intravenously as a bolus after the initiation of remifentanil infusion following endotracheal intubation. The same dose was repeated if the duration of surgery exceeded 60 minutes.
ketamin infusion
Ketamine was administered intravenously at 0.25 mg/kg/hour after the initiation of remifentanil infusion following endotracheal intubation and was continued until the end of surgery.
Normal Saline
Participants in the control group did not receive ketamine. A 100 mL normal saline infusion was initiated concurrently with the remifentanil infusion.
Locations (1)
SBÜ İstanbul Bağcılar Training and Research Hospital
Istanbul, Turkey (Türkiye)