Clinical Research Directory

Key Inclusion Criteria: 1. Participants must have a confirmed diagnosis of CLE. Diagnosis must be clinically and histologically confirmed,with or without SLE manifestations. 2. CLASI-A total score ≥ 8 points at Screening and confirmed at randomization. 3. Inadequate response or intolerant to antimalarial therapy. 4. Currently receiving at least one of the SoC CLE medications. Key Exclusion Criteria: 1. Any active skin conditions other than CLE that may interfere with the study (e.g., psoriasis, non-LE skin lupus, drug-induced lupus). 2. Active lupus nephritis or moderate-to-severe or chronic kidney disease. 3. Study participant has any medical or psychiatric condition (including conditions due to neuropsychiatric SLE) that, in the opinion of the Investigator, could jeopardize or would compromise the study participant's ability to participate in this study. This includes study participants with a life-threatening condition 4. History of chronic, recurrent (3 or more of the same type of infection in a 12-month period). 5. Has a history of severe herpes infection