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Comparison of Mean Arterial Pressure After Endotracheal Intubation in Patients Undergoing Spine Surgery With Pre-emptive Nitroglycerine Versus Dexmedetomidine
Sponsor: Mayo Hospital Lahore
Summary
This randomized controlled study compared nitroglycerine and dexmedetomidine for controlling blood pressure after insertion of a breathing tube in adults undergoing spine surgery under general anesthesia. The study hypothesis was that average blood pressure, measured as mean arterial pressure, differed between patients who received the two medicines. The study included 80 patients aged 18-60 years at the Department of Anesthesia, King Edward Medical University and its affiliated hospital in Lahore, Pakistan. Patients were randomly assigned by a lottery method to two groups of 40. One group received nitroglycerine through an intravenous infusion, while the other received dexmedetomidine. Both groups received the same general anesthesia protocol. Blood pressure was recorded before anesthesia and five minutes after insertion of the breathing tube. The main outcome was mean arterial pressure at five minutes after tube insertion, which was compared between the two groups.
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-01-10
Completion Date
2026-06-10
Last Updated
2026-10-28
Healthy Volunteers
No
Conditions
Interventions
Nitroglycerin (NTG)
Nitroglycerin was administered by intravenous infusion at 120 micrograms/kg/hour and titrated to the target mean arterial pressure.
Dexmedetomidine
Dexmedetomidine was administered intravenously, followed by a continuous infusion at 1.0 microgram/kg/hour, titrated to the target mean arterial pressure.
Locations (1)
Mayo Hospital, Lahore
Lahore, Punjab Province, Pakistan