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Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs
Sponsor: George Washington University
Summary
Drug overdose is a national crisis. The primary cause of death associated with opioids is opioid-induced respiratory depression. Naloxone (Narcan) which is the first line of defense for opioid overdose can reverse OIRD (Opioid-Induced Respiratory Depression), but in post-operative patients it will abolish pain control. There are no medications that can prevent OIRD. Pre-clinical studies provided evidence that intranasal (administered via a nasal spray) oxytocin may prevent and treat OIRD without interfering with pain control.
Official title: A Prospective, Single-center, Randomized, Blinded Study to Evaluate the Efectiveness of Intranasal Oxytocin in Prevention of Opioid Induced Postoperative Sleep Apnea in Bariatric Surgery Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2027-05-15
Completion Date
2030-07-14
Last Updated
2026-10-29
Healthy Volunteers
No
Conditions
Interventions
Intranasal Oxytocin 40 i.u.
Intranasal oxytocin dose of 40 international units
Intranasal Placebo Spray
This is a placebo comparator intranasal spray