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NOT YET RECRUITING
NCT07902830
PHASE2

A Study to Investigate the Safety and Tolerability of Granulocyte-colony Stimulating Factor (G-CSF) Dosage Reduction in Mavorixafor-treated Participants With Acquired Primary Autoimmune and Idiopathic Chronic Neutropenia Disorders

Sponsor: X4 Pharmaceuticals

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the safety and tolerability of G-CSF dosage reduction with mavorixafor in participants with autoimmune neutropenia (AIN) and chronic idiopathic neutropenia (CIN) disorders as assessed by the ability to safely reduce G-CSF dosage with mavorixafor treatment while maintaining clinically acceptable absolute neutrophil count (ANC) levels.

Official title: A Phase 2b, Single-arm, Open-label, Multicenter Study to Evaluate the Safety and Tolerability of G-CSF Dosage Reduction With Mavorixafor in Participants With Acquired Primary Autoimmune and Idiopathic Chronic Neutropenia Disorders

Key Details

Gender

All

Age Range

12 Years - Any

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2026-12

Completion Date

2029-01-30

Last Updated

2026-10-29

Healthy Volunteers

No

Interventions

DRUG

Mavorixafor

Mavorixafor will be administered per schedule specified in the arm description.