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A Study to Investigate the Safety and Tolerability of Granulocyte-colony Stimulating Factor (G-CSF) Dosage Reduction in Mavorixafor-treated Participants With Acquired Primary Autoimmune and Idiopathic Chronic Neutropenia Disorders
Sponsor: X4 Pharmaceuticals
Summary
The purpose of this study is to evaluate the safety and tolerability of G-CSF dosage reduction with mavorixafor in participants with autoimmune neutropenia (AIN) and chronic idiopathic neutropenia (CIN) disorders as assessed by the ability to safely reduce G-CSF dosage with mavorixafor treatment while maintaining clinically acceptable absolute neutrophil count (ANC) levels.
Official title: A Phase 2b, Single-arm, Open-label, Multicenter Study to Evaluate the Safety and Tolerability of G-CSF Dosage Reduction With Mavorixafor in Participants With Acquired Primary Autoimmune and Idiopathic Chronic Neutropenia Disorders
Key Details
Gender
All
Age Range
12 Years - Any
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2026-12
Completion Date
2029-01-30
Last Updated
2026-10-29
Healthy Volunteers
No
Conditions
Interventions
Mavorixafor
Mavorixafor will be administered per schedule specified in the arm description.