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Lemborexant on Perioperative Sleep Quality in Patients With Parkinson's Disease Undergoing Deep Brain Stimulation
Sponsor: Beijing Tiantan Hospital
Summary
This study tests whether lemborexant, an approved sleep medicine, can improve sleep and recovery in people with Parkinson's disease undergoing deep brain stimulation (DBS) surgery. Sleep problems are common around surgery and may worsen pain and slow recovery. Participants will be randomly assigned to take lemborexant or a placebo the night before surgery. Researchers will compare anesthesia use, wake-up time, sleep quality (objective and subjective), pain, recovery, and blood markers. The study will show whether lemborexant is safe and helpful for this group.
Official title: Effect of Lemborexant on Perioperative Sleep Quality in Patients With Parkinson's Disease Undergoing Deep Brain Stimulation: A Randomized, Double-blinded, Placebo-controlled Clinical Trial
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
128
Start Date
2026-11-01
Completion Date
2027-12-31
Last Updated
2026-10-29
Healthy Volunteers
No
Interventions
Lemborexant 5 mg
Participants will receive a single oral dose of lemborexant 5 mg tablet on the night before surgery.
Placabo
Participants will receive a oral dose of matching placebo tablet on the night before surgery.