Clinical Research Directory

Inclusion Criteria: * Patients scheduled for elective craniotomy for brain tumor resection * Age 18-65 years * ASA physical status I-III * Preoperative sleep disturbance, defined as Pittsburgh Sleep Quality Index (PSQI) score \> 5 * Signed informed consent Exclusion Criteria: * Tumor located in the brainstem, thalamus, Wernicke's area, Broca's area, or frontal pole * Severe neurological deficit with Karnofsky Performance Status (KPS) \< 60 * Active epilepsy or poorly controlled epilepsy * Chronic use of sedative-hypnotic medications * Acute psychiatric illness * Severe sleep apnea, COPD, severe daytime sleepiness (Epworth Sleepiness Scale \[ESS\] score ≥ 16), or history of narcolepsy and/or cataplexy * Severe hepatic or renal impairment * Use of systemic moderate or strong CYP3A inhibitors and/or inducers within 1 week before surgery * Any condition that, in the opinion of the principal investigator, precludes participation in the study