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Effect of Paracetamol Administration Timing on Oxidative Stress in Children Undergoing Sevoflurane Anesthesia
Sponsor: University of Belgrade
Summary
This study investigated the effects of paracetamol administration on oxidative stress in children undergoing inguinal hernia surgery under sevoflurane-based general anesthesia. Oxidative stress occurs when the production of potentially harmful molecules exceeds the body's antioxidant defenses. Anesthesia and surgery may influence this balance. The study compared two groups of children who received intravenous paracetamol at different stages of anesthesia. In one group, paracetamol was administered before premedication with midazolam and induction of anesthesia with sevoflurane. In the other group, paracetamol was administered after midazolam premedication and induction of anesthesia. Blood samples were collected at four predefined time points to measure markers of oxidative stress and antioxidant defense. The aim was to determine whether the timing of paracetamol administration influenced oxidative stress parameters in children undergoing surgery.
Official title: Effect of Paracetamol on Oxidative Stress Parameters in Pediatric Patients Undergoing Inguinal Hernia Surgery During Sevoflurane-Based Anesthesia
Key Details
Gender
All
Age Range
2 Months - 18 Years
Study Type
INTERVENTIONAL
Enrollment
49
Start Date
2019-07-29
Completion Date
2023-04-25
Last Updated
2026-10-29
Healthy Volunteers
No
Conditions
Interventions
paracetamol (acetaminophen) solution commercial
Intravenous paracetamol (10 mg/mL formulation) was administered over 15 minutes. In the PS group, paracetamol was administered before midazolam premedication and induction of anesthesia with sevoflurane. In the SP group, paracetamol was administered after midazolam premedication and induction of anesthesia with sevoflurane. Both groups underwent sevoflurane-based general anesthesia according to the same anesthetic protocol. The intervention under investigation was the timing of paracetamol administration in relation to premedication and anesthetic induction.
Locations (1)
Institute for Mother and Child Health Care of Serbia "Dr Vukan Čupić"
Belgrade, Serbia