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Comparison of Ciprofol, Remimazolam and Propofol in Laparoscopic Colorectal Surgery
Sponsor: The First Affiliated Hospital of Zhengzhou University
Summary
This is a single-center, prospective, parallel randomized controlled trial. A total of 180 patients aged 18-75 years undergoing elective laparoscopic colorectal surgery with ASA physical status Ⅰ-Ⅲ will be enrolled and randomly assigned in a 1:1:1 ratio to ciprofol group, remimazolam group or propofol group. All patients receive standardized background anesthesia regimen including dexmedetomidine, sufentanil, rocuronium and remifentanil. The primary outcome is the QoR-15 score at postoperative day 1. Secondary outcomes include intraoperative hemodynamic parameters, anesthesia recovery indicators, postoperative VAS pain scores, opioid consumption and perioperative adverse events. The study was approved by the Institutional Review Board of The First Affiliated Hospital of Zhengzhou University (approval number: 2023-KY-0137-002). Written informed consent will be obtained from each participant before enrollment.
Official title: The Effect of Different Intravenous Anesthetics on Postoperative Recovery Quality in Patients Undergoing Elective Laparoscopic Colorectal Surgery: A Single-Center, Prospective, Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
180
Start Date
2023-02-01
Completion Date
2024-12-31
Last Updated
2026-10-29
Healthy Volunteers
No
Interventions
Ciprofol
Ciprofol injection, intravenous anesthesia induction and maintenance for laparoscopic colorectal surgery.
Remimazolam
Remimazolam injection, intravenous anesthesia induction and maintenance for laparoscopic colorectal surgery.
Propofol
Propofol injection, intravenous anesthesia induction and maintenance for laparoscopic colorectal surgery.
Locations (1)
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China