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Multicenter Study for External Validation of the TB-NET Score
Sponsor: Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Summary
This is a retrospective, observational, multicenter study aiming to externally validate the TB-NET Score in an independent cohort of patients with advanced well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) or lung carcinoids. The primary objective is to validate the prognostic value of the TB-NET Score for progression-free survival (PFS). Secondary objectives include the evaluation of overall survival (OS), objective response rate (ORR), grade 3-4 adverse events, biochemical and functional imaging correlates, and the potential additional prognostic value of tumor growth rate (TGR).
Official title: Multicentric Study for External Validation of the TB-NET Score
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
400
Start Date
2026-05-12
Completion Date
2027-09
Last Updated
2026-10-29
Healthy Volunteers
No
Conditions
Locations (11)
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Mallinckrodt Institute of Radiology
St Louis, Missouri, United States
Hospital Sírio-Libanês
São Paulo, São Paulo, Brazil
Hôpital Beaujon
Clichy, France
Universitätsklinikum Erlangen
Erlangen, Bavaria, Germany
IRCCS Ospedale San Raffaele
Milan, Lombardy, Italy
University Hospital in Kraków
Krakow, Lesser Poland Voivodeship, Poland
Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, Spain
Hospital Universitario Fundación Jiménez Díaz
Madrid, Madrid, Spain
Uppsala University Hospital
Uppsala, Uppsala County, Sweden
Lausanne University Hospital (CHUV)
Lausanne, Canton of Vaud, Switzerland