Clinical Research Directory

Inclusion Criteria: 1. Age ≤ 16 years old\>1 year old, gender not limited; 2. Diagnosed as severe aplastic anemia according to the Camitta criteria; The degree of proliferation of bone marrow cells is less than 25% of normal; If ≥ 25% of normal but\<50%, the remaining hematopoietic cells should be\<30%; Blood count should be specific to two of the following three items: The absolute value of neutrophils is less than 0.5 × 109/L; Platelet count\<20 × 109/L; The absolute value of reticulocytes is less than 20 × 109/L. 3. Not suitable or willing to undergo hematopoietic stem cell transplantation (HSCT) directly; 4. The guardians voluntarily allow the ward to participate and sign an informed consent form; Exclusion Criteria: 1. Individuals with a history of hematopoietic stem cell transplantation; 2. Patients with uncontrolled bleeding and/or infection after standardized treatment prior to enrollment; 3. Previously or screened as HIV infected or carrier, or positive for hepatitis C antibodies; 4. History of liver cirrhosis or portal hypertension in the past; 5. Screening for subjects who have developed any malignant solid tumors of any organ system within the past 5 years, regardless of whether or not Already treated, metastasized or recurrent; Subjects with blood tumors found in the past or during screening; 6. Participated in other clinical trials within the first 3 months of randomization; 7. The researcher believes that there is any possibility that the subject may not be able to complete the study or be given any guidance Other situations with obvious risks. 8. Patients with congenital aplastic anemia -