Clinical Research Directory

Inclusion Criteria: 1. Veteran 2. Current post-traumatic stress disorder (PTSD) symptoms 3. Medically healthy 4. Body weight of ≥ 120 pounds (55 kilograms) 5. Participants must be able to participate and willing to give written informed consent and to comply with the study restrictions Exclusion Criteria: 1. Major medical issues 2. Medical conditions that could alter the absorption, metabolism or elimination of study drug 3. Family history of sudden death or ventricular arrhythmia 4. History of glaucoma 5. History, including family history, of motor tic or diagnosis of Tourette's syndrome 6. Pregnancy or lactation 7. Lifetime history of a chronic psychotic disorder or bipolar disorder type I 8. Lifetime history of stimulant use disorder 9. Current moderate or severe substance use disorder for any other substances 10. High suicidal risk 11. Marked anxiety, tension, or agitation, based on clinical observation, that is not due to an outside identifiable, transient, or modifiable cause 12. Unable to abstain from alcohol the evening before or day of study drug administration 13. History of a traumatic brain injury (TBI) resulting in loss of consciousness for more than 30 minutes 14. Drugs of abuse as determined by a positive urine test, excepting THC 15. Current use of any psychotropic medication that has not been at a stable dose 16. Current or recent use of a monoamine oxidase inhibitor or any other medication deemed by the study physician to exhibit an unsafe interaction with methylphenidate (MPH) 17. Past intolerance to methylphenidate (MPH) or any other psychostimulant 18. Current uncontrolled hypertension 19. Current heavy smoker and/or heavy caffeine consumption and unable to limit on study days 20. Abnormal Electrocardiogram, per study physician 21. Participation in a clinical trial with an investigational drug or a device within 30 days prior to dosing. 22. Concurrent participation in an evidence-based behavioral therapy treatment for PTSD 23. Volunteers who are unable to understand the informed consent form(s) and complete the study procedures including clinical testing 24. Any other reason, per study investigators, that would put the participant at undue risk or interfere with the conduct of the study per protocol