Clinical Research Directory

Inclusion Criteria: (I) General Inclusion Criteria * Aged 16 years to 90 years. For participants age 16-20, an assent form will be used and the legally authorized representative (LAR) will be consented * \>3 weeks from incident event * Diagnosis of as stroke, brain injury or SCI confirmed by neuroimaging and admitting specialists * Assessed by treating clinician to be able to understand and comply to programme requirements (e.g. safe use of ART and purpose) * Availability of suitable carer to ensure safety of participants during home ART training and follow up, if needed * Suitable and stable home environment to allow for use of ART (minimum of 1.5m x1.5m space if robots or VR exergames used)\* * Being able to follow instruction and give consent. * Home environment assessment by therapist may be needed to ensure appropriate training environment (II) ART-Specific Inclusion Criteria (using Oxford Medical Research Counicl MRC scale 0-5/5) * HMAN(arm): MRC grade ≥ 2/5 shoulder/elbow * ReHandyBot (hand): MRC grade ≥ 1/5 finger flexion or extension * Esoglove (hand): MRC grade ≥ 1/5 finger flexion or extension * EzyGain: either UE/LE MRC grade ≥3/5 (antigravity) * TrainFES (upper or lower limb): MRC grade \<4, targeted impairments are not due to lower motor neuron lesions * ezyGain (VR): UL and LL MRC grade≥3/5 MRC grade (subject to clinician evaluation) * Transcranial direct current stimulation (tDCS): Sum of Medical Research Council grades for shoulder abduction and finger Extension (SAFE) ≤ 8, prescribed with functional training tasks during tDCS Exclusion Criteria: (I) General Exclusion Criteria * Uncontrolled medical conditions (e.g., Unstable angina, untreated hypertension, sepsis/fever) * Sitting or orthostatic intolerance \<30 minutes (unless device can be performed supine) * Presence of seizures within 6 months of screening or a history of epilepsy or anti-epileptic medications * End stage organ failure (e.g. renal failure, cardiac failure) on organ replacement therapy * Anticipated life expectancy \< 6 months. * Psychiatric conditions precluding safe use of ART * Pressure sores (decubitus ulcers) or wounds /poor skin conditions at point of contact with ART * Severe spasticity (spasticity Modified Ashworth Scale (MAS \>2) * Presence of contractures, joint or limb limitations of range of movement to preclude safe and effective application of robotics/ FES (joint replacements allowed) * Significant pain (Visual Analogue Scale VAS\>5/10) deemed to potentially worsen with ART * Unhealed /active fractures * Presence of known contact allergies to ART interfaces * Presence of lower motor neuron causes of weakness / myopathies /myositis * Pregnancy or Lactation status (II) ART-Specific Exclusion Criteria * TrainFES (upper or lower limb): Presence of pacemaker, defibrillator or other implanted metallic or electronic device. * tDCS: Presence of cranial surgery, cochlear implant, ventriculoperitoneal (VP) shunt