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PRP Versus Saline Hydrodissection for CTS RCT
Sponsor: Medical University of Lodz
Summary
This single-center, single-blind, randomized controlled trial compared two injectates used for ultrasound-guided hydrodissection of the median nerve in adults with carpal tunnel syndrome: autologous platelet-rich plasma (PRP) and 0.9% normal saline (NS). Participants received a single hydrodissection with 5 mL of the allocated injectate per treated wrist; in participants with bilateral carpal tunnel syndrome, both wrists were treated with the same injectate. Symptom severity and functional status (Boston Carpal Tunnel Questionnaire), neuropathic pain (DN4 questionnaire), median nerve cross-sectional area on ultrasound, and grip strength parameters were assessed at baseline and at 3 and 6 months after the intervention. The study aimed to determine whether PRP provides benefit beyond the mechanical effect of hydrodissection with saline.
Official title: Platelet-Rich Plasma Versus Saline Hydrodissection for Carpal Tunnel Syndrome: A Randomized Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
21
Start Date
2025-03-23
Completion Date
2026-01-28
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
Autologous platelet-rich plasma
Approximately 5 mL of autologous platelet-rich plasma prepared from 15 mL of venous blood with the Arthrex ACP double-syringe system (centrifugation at 1500 rpm for 5 minutes), injected circumferentially around the median nerve under ultrasound guidance.
Normal Saline (0.9% Sodium Chloride)
5 mL of 0.9% sodium chloride injected circumferentially around the median nerve under ultrasound guidance from a masked syringe.
Ultrasound-guided median nerve hydrodissection
Single ultrasound-guided hydrodissection of the median nerve at the carpal tunnel inlet (pisiform-scaphoid level) using a 22-gauge needle and an in-plane ulnar approach; the injectate is delivered circumferentially to separate the nerve from the flexor retinaculum, subsynovial connective tissue and flexor tendons. No local anesthetic is used.
Locations (1)
Medical University of Lodz
Lodz, Łódź Voivodeship, Poland