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The Effect of Different Exercise Training Programs on Muscle Oxygenation in Individuals With Knee Osteoarthritis
Sponsor: Bahçeşehir University
Summary
Knee osteoarthritis can cause pain, reduced muscle strength, and difficulty with daily activities. Exercise is commonly used to manage knee osteoarthritis, but the effects of different exercise programs on muscle oxygenation are not fully understood. This study will compare three 6-week exercise programs in adults with knee osteoarthritis: aerobic exercise on a recumbent bicycle, lower-limb strengthening exercise, and a program combining aerobic and strengthening exercise. Participants will be randomly assigned to one of the three groups. Each group will attend three supervised exercise sessions weekly for 6 weeks. All participants will also receive a home stretching program. Participants will be assessed before the program, at weeks 3 and 6, and again at week 10, after a 4-week period without supervised exercise. The study will examine whether the exercise programs improve muscle oxygenation and whether changes in muscle oxygenation are associated with changes in muscle strength, pain, and physical function. The investigators expect muscle oxygenation to improve after the exercise programs and expect these changes to be associated with improvements in clinical measures.
Official title: The Effect of Different Exercise Training Programs on Muscle Oxygenation, Strength, Pain, and Functionality in Individuals With Knee Osteoarthritis
Key Details
Gender
All
Age Range
45 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2026-10-20
Completion Date
2027-12-20
Last Updated
2026-10-29
Healthy Volunteers
No
Conditions
Interventions
Recumbent-Cycle Aerobic Exercise
Supervised aerobic exercise on a recumbent cycle ergometer, three times per week for 6 weeks (18 sessions). Each session includes a 5-minute warm-up and a 5-minute cool-down. At the beginning of the program, the main cycling will be at 40% to 50% of age-predicted maximum heart rate. Duration and intensity are progressed according to participant tolerance, with a target at 60% to 70% of maximum heart rate by week 6. Cadence is 60 to 80 revolutions per minute. Heart rate and perceived exertion are monitored during exercise.
Lower-Limb Strengthening Exercise
Supervised bilateral lower-limb strengthening exercise, three times per week for 6 weeks (18 sessions). Exercises include isometric knee extension, hip flexion, extension, abduction and adduction, clamshell exercise, and knee flexion and extension using ankle weights. Participants perform 1 to 3 sets of 8 to 12 repetitions, with 90 to 120 seconds of rest between sets. Resistance starts at approximately 30% of one-repetition maximum and may progress toward 60%, according to tolerance and pain response. One-repetition maximum is reassessed every 2 weeks.
Home Flexibility Exercise Program
Home flexibility exercises provided to participants in all three arms. The program includes bilateral standing hamstring and quadriceps stretches and a towel-assisted gastrocnemius stretch. Each stretch is held at the point of tension for 20 to 30 seconds. Participants are asked to perform the exercises 3 to 5 days per week.
Locations (1)
İstanbul University Cerrahpaşa, Faculty of Health Science, Physiotherapy and Rehabilitation Lab
Istanbul, Turkey (Türkiye)