Inclusion Criteria:
* Age ≥ 18 year, and voluntarily signed the Informed Consent Form (ICF);
* Histologically confirmed B-cell non-Hodgkin lymphoma (defined according to the 5th edition of the WHO classification), pathological subtypes include large B-cell lymphoma and others.
* Pathologically confirmed positive expression of CD19 antigen on tumor cells.
* Participants with relapsed/refractory B-cell non-Hodgkin lymphoma after failure of standard treatment.
* At least one measurable lesion according to the 2014 Lugano Response Criteria for Lymphoma;
* ECOG performance status score of 0-1;
* Expected survival of at least 3 months;
* Adequate organ and bone marrow function;
* Eligible participants (males and females) of reproductive potential must agree to use a reliable method of contraception (hormonal contraception, barrier method, or abstinence) with their partner during the trial and for at least 1 year after dosing. Female participants of childbearing potential must have a negative serum pregnancy test within 7 days prior to enrollment. In addition, female participants must agree not to donate oocytes (eggs, ova) for assisted reproductive technology for 1 year after dosing, and male participants must agree not to donate sperm for assisted reproductive technology for 1 year after dosing;
* Willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
Exclusion Criteria:
* History of other malignancy within 3 years or concurrent other active malignancy (participants with cured localized tumors such as basal cell carcinoma of the skin, squamous cell carcinoma of the skin, superficial bladder cancer, carcinoma in situ of the prostate, carcinoma in situ of the cervix, carcinoma in situ of the breast, etc., may be enrolled);
* Participants with bleeding diathesis, active bleeding, hemoptysis, or history of major bleeding within the previous 6 months; tumor invasion of major blood vessels shown by imaging (CT or MRI), or tumor judged by the investigator as highly likely to invade major blood vessels and cause fatal massive bleeding during the subsequent study period;
* Participants with B-cell non-Hodgkin lymphoma involving the central nervous system;
* Received autologous hematopoietic stem cell transplantation within 3 months prior to the first dose;
* Previous allogeneic bone marrow transplantation, gene therapy, or adoptive cell therapy (including CAR-T therapy);
* Received anti-PD-1, anti-PD-L1, or T-cell engager therapy within 3 months prior to the first dose; received fludarabine or bendamustine within 6 months prior to the first dose;
* Adverse events from prior antineoplastic therapy have not recovered to CTCAE Version 6.0 grade ≤1 (except for alopecia or other toxicities without safety risk as judged by the investigator);
* Other prior therapies:Major surgery or curative radiotherapy within 28 days prior to dosing; Antibody-based targeted therapy or immunotherapy within 28 days or 5 half-lives (whichever is shorter) prior to dosing; Palliative radiotherapy within 14 days prior to dosing; Chemotherapy or small-molecule targeted therapy within 14 days or 5 half-lives (whichever is shorter) prior to dosing
* Simultaneously participating in another clinical trial, unless it is an observational (non-interventional) clinical trial or in the follow-up phase of an interventional trial (without impact on the follow-up data of this study);
* Received live vaccine within 4 weeks prior to dosing;
* Active bacterial, fungal, or viral infection prior to dosing. Individuals receiving prophylactic antimicrobial therapy without clinical manifestations of active infection prior to dosing may be considered for enrollment;
* Autoimmune disease requiring systemic therapy;
* History of central nervous system disease or current persistent central nervous system disease that may interfere with neurological assessments;
* History of immunodeficiency or positive HIV antibody test during screening;
* History of tuberculosis treatment within 2 years prior to dosing; history of active syphilis;
* Active hepatitis B or hepatitis C during screening. Active hepatitis B is defined as HBsAg-positive and HBV DNA \> ULN; Active hepatitis C is defined as HCV antibody-positive and HCV RNA \> ULN;
* History of severe cardiovascular disease;
* Hypersensitivity or intolerance to excipients of SYS6055 (primarily human serum albumin) or reconstitution solvent (with 5% human serum albumin).
* Any other conditions in participants that may interfere with compliance with study procedures, are not in the best interest of participants, or may affect study results: e.g., history of psychiatric disorders, drug addiction or substance abuse, any other clinically significant diseases or conditions, etc.;
* Pregnant or lactating female;
* Any other reason judged by the investigator that the participant is not suitable for participation in this clinical trial.
