Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
NOT YET RECRUITING
NCT07905638

Comparative Study of the Genomic Characteristics of Uropathogenic Escherichia Coli According to the Severity of Community-Acquired Urinary Tract Infections in Guadeloupe (COLIGENURI)

Sponsor: Centre Hospitalier Universitaire de la Guadeloupe

View on ClinicalTrials.gov

Summary

The aim is to identify genomic determinants (genes or gene clusters) associated with the severity of community-acquired E. coli urinary tract infections in Guadeloupe through a comparative approach integrating clinical, microbiological, and genomic data (GWAS approach).

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

210

Start Date

2026-10

Completion Date

2029-10

Last Updated

2026-10-29

Healthy Volunteers

No

Interventions

GENETIC

Whole-genome sequencing (WGS) of E. coli isolates (applies to all 3 groups)

Illumina sequencing of the E. coli isolate stored from the index urine culture, followed by bioinformatic analysis: assembly (SPAdes), annotation (Prokka), virulence and resistance genes and mobile genetic elements (VFDB, ResFinder), MLST/cgMLST typing, core-genome SNP phylogeny and pan-GWAS. Performed on strains collected during routine care; no additional procedure for patients.