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Comparative Effects of tDCS and tACS on Pain, Dexterity, and Strength in Diabetic Peripheral Neuropathy
Sponsor: University of Management and Technology Lahore
Summary
This study will be to compare the effects of transcranial direct current stimulation and transcranial alternating current stimulation on neuropathic pain, manual dexterity and isometric muscle strength in diabetic peripheral neuropathic patients. Study design will be randomized clinical trial. Evaluation will be done by using McGill Pain Questionnaire-2, Digital force gauge sf-500 and wooden 9 hole peg board. Non-probability convenient sampling will be used and 38 subjects will be allocated to two groups by random allocation. Group A will receive TDCS and Group B will receive TACS. Both groups will receive hot pack, and ROM exercises of upper extremity before techniques application. Both groups will receive 20 sessions for the period of 4 weeks. Measurements of all the outcome variables will be taken at baseline and 4th week.
Official title: Comparative Effects of Transcranial Direct Current Stimulation and Transcranial Alternating Current Stimulation on Neuropathic Pain, Manual Dexterity and Strength in Diabetic Peripheral Neuropathic Patients.
Key Details
Gender
All
Age Range
45 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
46
Start Date
2026-10-22
Completion Date
2026-12-31
Last Updated
2026-11-03
Healthy Volunteers
No
Conditions
Interventions
Transcranial Direct Current Stimulation (tDCS)
Transcranial Direct Current Stimulation (tDCS) will be applied over the primary motor cortex (M1) hand area corresponding to the C3 position according to the International 10-20 EEG system. The anodal electrode will be positioned over C3, while the cathodal electrode will be placed over the right supraorbital region. Saline-soaked sponge electrodes measuring 5 × 5 cm will be used for stimulation. A direct current of 2 mA will be delivered for 20 minutes per session. The intervention will be administered once daily, five days per week, for a total of 20 sessions over a period of 4 weeks.
Transcranial Alternating Current Stimulation (tACS)
Transcranial Alternating Current Stimulation (tACS) will be applied targeting the frontal cortex and the primary motor cortex (M1). Stimulation will be delivered at an intensity of 2 mA with a frequency of 5 -10 Hz bilaterally. Each treatment session will last 20 minutes. The intervention will be administered daily for five days per week according to the treatment schedule. Standardized electrode placement and stimulation parameters will be maintained throughout the intervention period to ensure consistency across sessions.
Locations (1)
University of Management & Technology
Lahore, Punjab Province, Pakistan