Clinical Research Directory

Magnesium Kinetics During Citrate-Anticoagulated CRRT

Sponsor: Region Skane

Summary

The goal of this observational study is to assess how continuous renal replacement therapy (CRRT), a type of dialysis used in critically ill patients, affects magnesium levels in adults treated in intensive care units (ICUs). The study focuses on CRRT using citrate, a substance that prevents blood clotting in the dialysis circuit. Participants will receive CRRT with citrate as part of their routine medical care. The main questions it aims to answer are: How does citrate affect the amount of free (ionized) magnesium in the blood How much magnesium is removed by the dialysis circuit during treatment? How do magnesium levels in the blood change over time during treatment? How does treatment affect calcium and phosphate levels and what changes occur in the body's acid-base balance and metabolism? Researchers will: Measure magnesium, calcium and phosphate levels in blood and dialysis circuit fluid samples collected before and during treatment, for up to 72 hours. Measure additional blood markers to assess changes in metabolism and acid-base balance. Record dialysis treatment settings and fluid flow rates. The collected measurements will be used to better understand how magnesium and other electrolytes are affected during CRRT with citrate.

Official title: Total and Ionized Magnesium Kinetics During Citrate-Anticoagulated Continuous Renal Replacement Therapy

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