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Acceptance and Committment Therapy Combined With Ketamine in Difficult-to-Treat Depression.
Sponsor: University of British Columbia
Summary
Ketamine is often used to treat depression where standard treatments have failed. Yet, even with ketamine, depression can persist and make it difficult to keep up with life. This study examines whether it is practical, safe and helpful to use a talk therapy (Acceptance and Commitment Therapy, ACT) in patients with difficult-to-treat depression receiving ketamine through the Ketamine Intervention Program at UBC Hospital. Researchers expect that combining ACT plus Ketamine ("K-ACT") will be feasible, safe, and will help patients functioning better in their daily lives, feeling that they are recovering, and having fewer symptoms of depression.
Official title: Recovery-focused Acceptance and Commitment Therapy Combined With Ketamine (K-ACT) for Patients With Difficult-to-treat Depression: a Feasibility Study.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2027-01
Completion Date
2028-06
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
K-ACT Intervention
Acceptance and Commitment Therapy (ACT) is an evidence-based psychological intervention that aims to help people develop acceptance of their experiences, awareness of the present moment, distance ("defusion") from one's thoughts/emotions, clarification of one's values, commitment to actions consistent with those values, and flexible experience of self. Through these processes, participants can develop better psychological flexibility, which in turn can support depression recovery. In this study, ACT is provided in parallel to a ongoing clinical ketamine treatment program for depression, within a Ketamine-Combined with Psychotherapy (KCP) framework.
Locations (1)
UBC Hospital
Vancouver, British Columbia, Canada