Clinical Research Directory

Inclusion Criteria: * Age 18-75 years. * Histologically or cytologically confirmed resectable stage III-IVB head and neck squamous cell carcinoma (HNSCC) of the oral cavity, oropharynx, hypopharynx, or larynx according to the AJCC 9th edition. * For oropharyngeal cancer, tumor tissue must be available for HPV/P16 testing (testing is not required if previously performed). * Tumor tissue (from the primary tumor or resected tumor) must be available for EGFR and PD-L1 immunohistochemical testing (testing is not required if previously performed); genetic testing may be performed when necessary. * ECOG performance status 0-1. * At least one measurable lesion according to RECIST 1.1. * Expected survival ≥6 months. * Adequate hematologic function: white blood cell count ≥3 × 10\^9/L; absolute neutrophil count ≥1.5 × 10\^9/L; platelet count ≥100 × 10\^9/L; hemoglobin ≥90 g/L. * Adequate renal function: serum creatinine ≤1.5 × ULN or creatinine clearance (CrCl) \>50 mL/min (using the Cockcroft-Gault formula): * Female CrCl = (140 - age) × body weight (kg) × 0.85 / (72 × Scr mg/dL); Male CrCl = (140 - age) × body weight (kg) × 1.00 / (72 × Scr mg/dL). * Adequate hepatic function: total serum bilirubin ≤1.5 × ULN; aspartate aminotransferase (AST) ≤2.5 × ULN; alanine aminotransferase (ALT) ≤2.5 × ULN. * Women of childbearing potential must have a negative pregnancy test within 2 weeks before the start of study treatment and must not be breastfeeding. -Female participants must agree to use effective contraception during the study and for 6 months after the last dose of study drug. Male participants must agree to use effective contraception during the study and for 6 months after the last dose of study drug. * Participants must voluntarily agree to participate, provide written informed consent, and be able to comply with the study visits and procedures specified in the protocol. Exclusion Criteria: * Prior radiotherapy or chemotherapy; prior immunotherapy targeting PD-1/PD-L1; prior EGFR monoclonal antibody, EGFR-TKI, or anti-angiogenic therapy. * Treatment with systemic or local corticosteroids within 4 weeks before enrollment. * HIV-positive; HBsAg-positive with detectable HBV DNA (quantitative ≥1000 copies/mL); or positive blood screening for chronic hepatitis C (HCV antibody-positive) with detectable HCV RNA. * Participation in another interventional clinical trial within 30 days before screening. * History of other malignancies (except cured basal cell carcinoma of the skin). History of primary immunodeficiency. * Presence of poorly controlled concomitant diseases (e.g., heart failure, severe pulmonary disease, severe liver disease, psychiatric disorders, etc.). * Major surgery within 90 days before the first dose of study drug or planned surgery. * Known allergy to any study drug or its components. * Pregnancy (confirmed by blood or urine HCG) or breastfeeding; or participants of childbearing potential (both male and female) who are unwilling or unable to use effective contraception until at least 6 months after the last study treatment. * Any condition that, in the investigator's opinion, makes the participant unsuitable for the study. * Unwillingness to participate in the study or inability to sign informed consent. Receipt of a live vaccine within 30 days before study drug administration.