Clinical Research Directory

Inclusion Criteria: 1. Age 18 to 75 years, male or female. 2. Confirmed diagnosis of great saphenous vein (GSV) trunk reflux with a reflux time \>0.5 seconds on lower extremity duplex ultrasound. 3. CEAP clinical classification of C2 to C6 (inclusive). 4. GSV trunk diameter (thigh segment) measuring 4 to 12 mm on pre-operative ultrasound. 5. Planned to undergo endovenous thermal ablation treatment for varicose veins. 6. Willing and able to provide written informed consent to participate in the study. Exclusion Criteria: 1. History of deep vein thrombosis (DVT) in the ipsilateral lower extremity. 2. ior surgical stripping or endovenous ablation treatment on the ipsilateral GSV. 3. Acute superficial venous thrombophlebitis in the ipsilateral lower extremity at the time of screening. 4. Concurrent lower extremity arterial disease with an ankle-brachial index (ABI) \<0.7. 5. Pregnancy or currently breastfeeding. 6. Known allergy or hypersensitivity to lidocaine, ropivacaine, or any amide-type local anesthetic agent. 7. Severe hepatic impairment (ALT or AST \>3 times the upper limit of normal). 8. Severe renal impairment (estimated glomerular filtration rate \<30 mL/min/1.73m²). 9. Severe cardiac dysfunction (New York Heart Association Class III or IV) or uncontrolled cardiac arrhythmia. 10. Coagulation abnormality (international normalized ratio \>1.5 or platelet count \<80 × 10⁹/L). 11. Diagnosis of severe psychiatric disorder or cognitive impairment that would interfere with the ability to provide reliable Visual Analog Scale (VAS) pain scores. 12. Planned bilateral simultaneous ablation procedure (both legs treated in the same session). 13. Chronic pain syndrome or long-term use of analgesic medications (regular use for \>3 months). 14. Any other condition that, in the investigator's judgment, would make the patient unsuitable for study participation.