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Effect of LMWH on Neonatal Outcomes in Isolated Oligohydramnios
Sponsor: PAEC General Hospital, Islamabad
Summary
The pregnant women who meet the study requirements will be included in the study. They will be randomly assigned to receive either the usual treatment or the usual treatment along with an additional medicine. The usual treatment will include fluids given through a vein, rest while lying on the left side, and a low-dose aspirin tablet (75 mg once daily) from the 22nd to the 34th week of pregnancy. Women will also receive 1,000 ml of 5% dextrose fluid daily through a vein, from the time low amniotic fluid is diagnosed until the 36th week of pregnancy. Some women will also receive an additional injection of a blood-thinning medicine called low-molecular-weight heparin (LMWH), at a dose of 40 mg under the skin, from the 22nd to the 36th week of pregnancy. All participants will undergo weekly ultrasound examinations to measure the fluid surrounding the baby and assess blood flow through the umbilical cord. The study will record the number of babies born before 37 weeks of pregnancy, the babies' birth weights, and the number of babies born alive.
Official title: Comparison of the Effect of Conventional Method Along With LMWH vs Conventional Method Alone in Improvement of Neonatal Outcomes in Pregnancies Complicated With Isolated Oligohydramnios in 2nd and 3rd Trimester.
Key Details
Gender
FEMALE
Age Range
20 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
106
Start Date
2026-10-24
Completion Date
2027-01-30
Last Updated
2026-10-30
Healthy Volunteers
No
Conditions
Interventions
Enoxaparin (LMWH)
Participants will receive conventional treatment, including left lateral positional rest, intravenous 1,000 mL of 5% dextrose daily until 36 weeks of gestation, and oral aspirin 75 mg once daily from 22 to 34 weeks. Additionally, subcutaneous low-molecular-weight heparin (LMWH) 40 mg will be administered from 22 to 36 weeks of gestation.
Dextrose Water
Participants will receive conventional treatment, including left lateral positional rest, intravenous 1,000 mL of 5% dextrose daily until 36 weeks of gestation, and oral aspirin 75 mg once daily from 22 to 34 weeks of gestation, without LMWH.
Locations (1)
Pakistan Atomic Energy Commission General Hospital
Islamabad, Federal, Pakistan