Clinical Research Directory

Cholecystectomy, Biliary Diseases, and Colorectal Adenoma Risk: A Real-World Retrospective Study

Sponsor: Nanjing First Hospital, Nanjing Medical University

Summary

This study is a retrospective real-world study based on the electronic medical record database of Nanjing First Hospital. By integrating data from the hospital information system, ultrasound system, endoscopy system, pathology system, surgery and anesthesia system, medical record front pages, laboratory system, and electronic medical records, the study aims to evaluate the relationship between a history of cholecystectomy and biliary tract-related diseases and the detection risk of colorectal adenoma, and further analyze their associations with advanced lesions including advanced adenoma, high-grade intraepithelial neoplasia, adenoma carcinogenesis, or colorectal cancer. Additionally, it will explore the impact of different biliary disease subtypes, time intervals after cholecystectomy, and adenoma location on the study results. If the study finds that cholecystectomy or specific biliary diseases are associated with an increased risk of colorectal adenoma and advanced lesions, it may provide a reference for risk stratification of colorectal tumor screening and optimization of colonoscopy follow-up strategies for patients with biliary diseases; if no clear association is found, it may also provide evidence for clinically reasonable assessment of screening needs and avoidance of over-examination.

Official title: Correlation Between Cholecystectomy and Biliary Tract-Related Diseases and the Risk of Colorectal Adenoma: A Retrospective Real-World Study Based on Hospital Information System Data

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