Clinical Research Directory
Browse clinical research sites, groups, and studies.
Tempo-controlled Low-load Resistance Training in Patients With Knee Osteoarthritis.
Sponsor: University of Management and Technology Lahore
Summary
This randomized controlled trial aims to evaluate the effects of tempo-controlled low-load resistance training compared to conventional low-load resistance training on pain, muscle performance, and functional disability in patients with knee osteoarthritis. The study will recruit 32 participants aged 40-65 with Grade I-II knee osteoarthritis and randomly allocate them into two groups for a 6-week intervention at Ch Rehmat Ali Memorial Trust Hospital. Group A will perform strengthening exercises (such as sit-to-stand, mini squats, and leg raises) using a controlled 3-1-3 second tempo cadence (eccentric, isometric hold, concentric), while Group B will perform the same exercises at a self-selected speed; both groups will receive preparatory moist heat, warm-ups, knee isometrics, and Maitland mobilizations three times weekly. Primary outcomes-including pain intensity (NPRS), functional difficulty (WOMAC), walking endurance (6MWT), and mobility (TUG)-will be evaluated at baseline and 6 weeks to determine if tempo control offers a more effective, well-tolerated alternative for managing knee osteoarthritis.
Official title: Effects of Tempo-Controlled Low-load Resistance Training on Pain, Muscle Performance and Disability in Patients With Knee Osteoarthritis.
Key Details
Gender
All
Age Range
40 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2026-10-27
Completion Date
2026-12-31
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
Tempo-controlled low-load resistance training
The intervention will include sit-to-stand, mini squats, straight leg raises, step-ups, terminal knee extensions, and seated knee extensions. Each exercise will be performed at a controlled tempo of 3 seconds eccentric, 1-second isometric hold, and 3 seconds concentric, with 3 sets of 10 repetitions and 1-minute rest intervals between sets. will receive treatment three times per week for six weeks.
Conventional Physiotherapy Training
Participants will receive the same initial physiotherapy treatment and strengthening exercises as Group A, but the exercises will be performed at a self-selected speed without tempo control. Each exercise will consist of 3 sets of 10 repetitions and will receive treatment three times per week for six weeks.
Locations (1)
UMT
Lahore, Punjab Province, Pakistan