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A Multi-modal Cohort Study of Brown Adipose Tissue Based on Paired Comparisons at Room Temperature and After Cold Exposure
Sponsor: Jinling Hospital, China
Summary
This study is a single-center, prospective clinical study that plans to prospectively recruit volunteers aged 18-40 years, including metabolically healthy individuals and those with diabetes mellitus and hyperlipidemia. Participants will undergo \[¹⁸F\]fluorodeoxyglucose positron emission tomography/computed tomography (\[¹⁸F\]FDG PET/CT) scans both at room temperature and after cold exposure. The planned sample size is 500 participants. The study will systematically collect baseline data, questionnaire responses, \[¹⁸F\]FDG PET/CT images acquired under both conditions, as well as saliva and blood samples. The study aims to establish a clinical-imaging-biological multimodal brown adipose tissue (BAT) cohort with paired pre- and post-cold exposure comparisons. Based on this cohort, we expect to achieve new breakthroughs in BAT detection methods, assessment criteria, and the understanding of its genetic mechanisms.
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2026-10-01
Completion Date
2028-12-31
Last Updated
2026-11-02
Healthy Volunteers
Yes
Conditions
Interventions
cold exposure
Participants will undergo saliva and blood collection and complete PET-CT scans both at room temperature and after cold exposure. The room-temperature PET-CT scan will be performed according to routine clinical protocols without the need for additional oral or injectable medications. For the post-cold-exposure scan, participants will only need to receive 2 hours of moderate cold exposure prior to the scan to adequately activate brown adipose tissue (they will be arranged to rest in a room maintained at 16-19 °C).
Locations (1)
Jinling Hospital
Nanjing, Jiangsu, China