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Rectal Administration of Mother's Own Milk and Growth in Preterm Infants
Sponsor: Azerbaijan Medical University
Summary
This retrospective observational cohort study evaluated whether rectal administration of mother's own milk was associated with feeding progression and growth in preterm infants. The study included 50 infants born between 27+0 and 32+6 weeks of gestation at a neonatal intensive care unit in Baku, Azerbaijan, between January 2023 and January 2026. All infants had delayed meconium passage beyond 48 hours after birth. Of the 50 infants, 29 received rectal administration of mother's own milk as part of clinical care, while 21 did not receive this intervention. Treatment was not randomly assigned. The primary outcome was time to full enteral feeding. Secondary outcomes included time to full oral feeding, hospital stay, and weight, length, and head circumference at 36 and 40 weeks' postmenstrual age. The study aimed to explore whether this clinical practice was associated with improved feeding and growth outcomes and to provide preliminary evidence for future clinical trials.
Official title: Rectal Administration of Mother's Own Milk in Preterm Infants: Feeding Progression and Growth to Term-Equivalent Age in a Retrospective Cohort Study
Key Details
Gender
All
Age Range
0 Days - 2 Days
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2023-01-01
Completion Date
2026-03-31
Last Updated
2026-11-02
Healthy Volunteers
No
Interventions
Rectal Administration of Mother's Own Milk
Infants received freshly expressed mother's own milk (2 mL/kg), warmed to body temperature, administered rectally once daily beginning 48 hours after birth and continuing until full enteral feeding was achieved. The milk was slowly administered over approximately 2 minutes through an 8-Fr silicone catheter lubricated with olive oil and inserted approximately 2-3 cm into the rectum. This treatment was provided as part of routine clinical care and was not assigned according to a prospective research protocol. Kopyala
Locations (1)
Educational Surgery Clinic of Azerbaijan Medical University
Baku, Azerbaijan