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RECRUITING
NCT07909109

An Open Label Pilot Study Assessing the Impact of Chromium Picolinate Supplementation on Appetite and Cravings in Overweight Individuals

Sponsor: Nutrition 21, Inc.

View on ClinicalTrials.gov

Summary

This open-label, decentralized pilot study evaluates the effects of daily chromium picolinate supplementation (8 mg providing 1,000 mcg chromium) for 8 weeks on appetite, food cravings, and food-related intrusive thoughts ("food noise"). The study aims to enroll up to 110 evaluable healthy adults aged 35-70 years with a body mass index (BMI) between 25 and 31 kg/m². Participants are stratified into two cohorts: those without prior Glucagon-Like Peptide-1 (GLP-1) receptor agonist exposure (Cohort 1, n=80) and those with prior GLP-1 exposure following a 14-to-90-day washout period (Cohort 2, n=30). Conducted entirely remotely via the Chloe mobile app, the study utilizes validated questionnaires (Food Cravings Questionnaire \[FCQ-T\], RAID-FN food noise inventory, appetite Visual Analogue Scales \[VAS\]), continuous glucose monitoring (CGM), daily meal logs, and weekly adverse event surveys to assess metabolic, behavioral, and subjective outcomes.

Key Details

Gender

All

Age Range

35 Years - 70 Years

Study Type

OBSERVATIONAL

Enrollment

138

Start Date

2026-08-31

Completion Date

2027-01

Last Updated

2026-11-02

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Study Product

All 138 Participants will receive similar study product.

Locations (1)

People Science

Los Angeles, California, United States