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Multimodal Assessment of NMES Effects on Respiratory and Peripheral Muscles in COPD
Sponsor: Universitas Padjadjaran
Summary
The goal of this clinical trial is to learn if targeted neuromuscular electrical stimulation (NMES) can treat respiratory and peripheral muscle weakness in patients with chronic obstructive pulmonary disease (COPD). The main questions it aims to answer are: * Does targeted NMES improve diaphragm thickening fraction and excursion as measured by diaphragm ultrasound? * What are the comparative effects of targeted NMES on plasma biomarkers, specifically Interleukin-6 (IL-6) and Insulin-like Growth Factor-1 (IGF-1)? Researchers will compare three groups: the first intervention group receiving intercostal NMES combined with Pursed-Lip Breathing (PLB), the second intervention group receiving quadriceps NMES combined with PLB, and a control group receiving sham upper trapezius NMES combined with PLB, to see if targeted NMES provides superior improvements in respiratory and peripheral muscle function. Participants will: * Undergo baseline screening, including a diaphragm ultrasound and a blood draw for plasma biomarkers (IL-6 and IGF-1) * Be randomly assigned to one of the three groups to receive either intercostal NMES, quadriceps NMES, or sham upper trapezius NMES, all combined with Pursed-Lip Breathing exercises * Complete a post-intervention assessment involving repeat ultrasound imaging and biomarker analysis to evaluate muscle and systemic changes
Official title: COMPARATIVE EFFECTS OF TARGETED NEUROMUSCULAR ELECTRICAL STIMULATION (NMES) ON RESPIRATORY AND PERIPHERAL MUSCLES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): A MULTIMODAL ASSESSEMENT USING DIAPHRAGM ULTRASOUND AND PLASMA BIOMARKERS (IL-6 AND IGF-1)
Key Details
Gender
All
Age Range
40 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2026-10
Completion Date
2028-03
Last Updated
2026-11-02
Healthy Volunteers
No
Interventions
Neuromuscular Electric Stimulation
Neuromuscular Electrical Stimulation (NMES) is a procedure that uses small electrical impulses delivered through electrodes on the skin to stimulate motor nerves and cause passive muscle contractions.
Exercise
Pursed-lip breathing is a simple respiratory exercise that involves inhaling slowly through your nose and exhaling gently through tightly puckered or "pursed" lips (as if whistling or blowing out a candle).
Locations (1)
Faculty of Medicine Universitas Padjadjaran
Bandung, West Java, Indonesia