Clinical Research Directory
Browse clinical research sites, groups, and studies.
Neurobiological Markers of Non-suicidal Self-injury and Treatment Mechanisms of Adolescent Self-injury Intervention Skills Training
Sponsor: Seoul National University
Summary
The goal of this clinical trial is to evaluate the effectiveness and safety of Adolescent Self-Injury Intervention Skills Training (ASIST), a treatment program developed by the research team, compared with treatment as usual (TAU) in adolescents who engage in non-suicidal self-injury (NSSI). The main questions it aims to answer are: 1. How do the effectiveness and safety of ASIST compare with those of treatment as usual in adolescents with NSSI? 2. How are treatment-related changes in psychological, clinical, behavioral, and biological measures associated with treatment response? 3. Can machine learning techniques be used to predict treatment responses in adolescents with NSSI? Researchers will compare adolescents receiving ASIST with those receiving TAU to examine changes in psychological, clinical, and behavioral characteristics before and after treatment. They will also examine changes in cortisol and beta-endorphin levels, as well as brain activity and functional connectivity during task performance, to explore potential mechanisms associated with treatment response. Participants will: 1. Receive either ASIST or TAU. 2. Complete psychological, clinical, and behavioral assessments before and after treatment. 3. Undergo measurements of cortisol and beta-endorphin levels. 4. Complete tasks during brain imaging assessments to measure brain activity and functional connectivity.
Key Details
Gender
All
Age Range
12 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2021-12-15
Completion Date
2027-12
Last Updated
2026-11-02
Healthy Volunteers
No
Interventions
Adolescent Self-Injury Intervention Skills Training (ASIST)
ASIST is a structured psychological intervention developed for adolescents who engage in non-suicidal self-injury. The program consists of four sessions delivered over four weeks, focusing on: (1) understanding self-injury, behavioral chain analysis, and safety planning; (2) identifying and modifying automatic thoughts, core beliefs, and rumination; (3) improving emotional awareness, expression, and regulation; and (4) developing stress management, coping, and interpersonal communication skills. The intervention incorporates cognitive behavioral and emotion regulation strategies. Participants with persistent clinically significant difficulties at the four-week follow-up may receive two additional sessions addressing cognitive and interpretation biases and difficulties identifying and expressing emotions.
Treatment as Usual (TAU)
Participants assigned to the TAU group will receive routine clinical care for non-suicidal self-injurious behavior over a 4-week period. Depending on their individual clinical needs, treatment may include psychoeducation, safety planning, behavioral chain analysis, counseling, and supportive psychotherapy, consistent with usual care practices in child and adolescent psychiatry.
Locations (1)
Seoul National University Hospital
Seoul, South Korea