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Curcumin-mediated Photodynamic Therapy Versus Photobiomodulation in the Treatment of Oral Erosive Lichen Planus
Sponsor: Alexandria University
Summary
Background: Oral Lichen Planus (OLP) is a chronic, T-cell-mediated inflammatory disease of the oral mucosa, with the erosive form causing painful ulcerations and erosions, significantly impacting the patient's quality of life and carrying a risk of malignant transformation. While corticosteroids remain the first-line treatment, their long-term use is limited by significant local and systemic side effects. Consequently, there is a critical need for effective, non-invasive and safe alternative therapies. Photodynamic Therapy (PDT) and Photobiomodulation (PBM) have emerged as promising light-based modalities. Curcumin, a natural polyphenol, has gained attention as a safe and effective photosensitizer for PDT due to its anti-inflammatory and antioxidant properties. Aim: This clinical trial aims to evaluate and compare the effect of nano-curcumin formulation incorporated into biodegradable mucoadhesive gel as a photosensitizer for Photodynamic Therapy (PDT) versus Photobiomodulation (PBM) in the treatment of oral erosive lichen planus.
Official title: Curcumin-mediated Photodynamic Therapy Versus Photobiomodulation in the Treatment of Oral Erosive Lichen Planus (a Randomized Clinical Trial)
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
42
Start Date
2026-09-30
Completion Date
2027-05-15
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
Nano- Curcumin-Mediated Photodynamic Therapy (PDT)
A standardized 1% nano-curcumin loaded biodegradable mucoadhesive gel will then be applied over the erosive lesion and its peripheral margins. Treatment will be administered twice weekly for four consecutive weeks, resulting in a total of eight treatment sessions per patient
Photobiomodulation Therapy (PBM)
Utilization of a Blue laser 445 nm for 45-60 seconds per spot in non-contact mode, then application of red laser 660nm Diode Laser \\ for 5-10 seconds per spot in non-contact mode. For blue laser Output configuration is at 100 mW and for Red laser output configuration is at 100 mW. Each patient will receive 2 sessions per week (a total of 8 sessions)
Locations (1)
Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt