Clinical Research Directory

Inclusion Criteria: * Adults aged 20 to 60 years, of any sex, with full capacity to provide informed consent. * Current clinical healthcare professionals working in relevant units at Shuang Ho Hospital who perform shift work, including evening or night shifts, and are exposed to sustained occupational stress. * In generally good physical and mental health, without severe acute illness, and able to wear physiological monitoring equipment and follow study procedures. * Willing to use the HRV monitoring device and study patches, complete questionnaires and diaries, and provide written informed consent. Exclusion Criteria: * Current or previous major psychiatric illness, such as severe depression, bipolar disorder or schizophrenia, or current treatment with antidepressants, anxiolytics or other psychiatric medications that may affect autonomic function or interfere with study assessments. * Known clinically significant arrhythmia, including atrial fibrillation or atrioventricular block; an implanted cardiac pacemaker; or severe cardiovascular disease, including uncontrolled hypertension or heart failure. * Frequent or long-term use of hypnotics or sedatives, including benzodiazepines or Z-drugs, or other medications that may substantially affect sleep or HRV, such as beta blockers. * Known allergy to adhesive materials, turmeric, plants in the ginger family or related patch ingredients; or severe eczema, wounds or other skin conditions that make patch application unsuitable. * Pregnancy or breastfeeding. Participants who become pregnant during the study discontinue further participation. * Other conditions judged by the research team to make participation unsuitable, including inability to complete study procedures, anticipated prolonged leave or departure from shift work, or plans for major changes in daily routines within the two weeks before study initiation.