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Personalized Metabolic Nutrition Sepsis Study
Sponsor: University of Pittsburgh
Summary
Children with sepsis, a condition in which infection causes organ dysfunction will be enrolled with parental permission in this study. Nutrition will be given according to their individual metabolic profiles until normalization of metabolism. Metabolism is the way that children process food to meet our body's needs, based on metabolic testing the children may need more or less carbohydrates, more or less fats or more or less protein. The investigators will measure whether normalization of metabolism with this personalized nutrition leads to resolution of organ dysfunction.
Official title: Personalized Metabolic Nutrition for Children With Sepsis
Key Details
Gender
All
Age Range
44 Weeks - 17 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2026-12-01
Completion Date
2031-11-30
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
For group Peds Sep A: Standard nutrition will be given
This intervention consists of the standard nutrition that is offered to patient's in the PICU
For Group Peds SepB: Low leucine, isoleucine formula
In this intervention instead of giving standard nutrition, a formula with low leucine and isoleucine will be given to patients in the PICU
For Group Peds Sep C: Medium chain triglyceride oil enriched formula.
In this group of subjects a formula that has medium chain triglyceride oil enrichment will be given to patients in the PICU
For Group Peds Sep D: Low carbohydrate ketogenic formula
This group of subjects will receive a low carbohydrate, ketogenic formula in the PICU.
Locations (1)
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States