Clinical Research Directory

Inclusion Criteria: Between the ages of 18 and 65; * Diagnosis of (\>1) CVA that occurred \>1 year prior to participation * understand instructions of exercise activity * Have a moderate motor impairment consistent with the results of the Fugl-Meyer for the upper extremity; * Safe for use of BFR tourniquet device (see exclusion criteria); * Able to elevate and hold a paretic arm for 2 seconds at 90° shoulder flexion, 160°-180° elbow extension, and neutral forearm supination; * \>20° gravity minimized wrist extension while holding a cylindrical object on a tabletop. Exclusion Criteria: * Bone or joint limitations that restrict paretic arm motion; * History of deep venous thrombosis, impaired circulation, or peripheral vascular compromise, * previous revascularization of the extremity, extremities with dialysis access, acidosis, extremity infection or tumor distal to tourniquet, * increased intracranial pressure, severe hypertension, any traumatic surgery or reconstruction of extremity distal to tourniquet, * skin grafts, lengthy immobilization of extremity, surgery or damage to lymph structures associated with paretic extremity, myocardial infarction or cardiac surgery, * chest pain * shortness of breath at rest or active cancer; * Currently taking or using medications and supplements known to increase clotting risk \< 1 month prior to participation; * Currently experiencing or at risk for a hypercoagulable state * Botox injections into the paretic arm within 4 months of participation * Positive classification on the Edinburgh Claudication Questionnaire Score \> 0 on Wells' criteria for DVT.