Clinical Research Directory
Browse clinical research sites, groups, and studies.
Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 Diabetes
Sponsor: University of Roma La Sapienza
Summary
Background: The study of factors associated with diabetic heart disease (DHD), the leading cause of mortality in diabetes, represents an unmet need. Autoimmune diabetes in adults (AID) and type 2 diabetes (T2D) differ in pathophysiology, vascular complications, and autonomic impairment, with significant implications for DHD, which results from a complex interplay among coronary micro- and macro-vascular circulation, neuro-immune control, and myocardial damage. Objective: To characterize the complexity of DHD and its determinants by comparing AID and T2D. Methods: DHD will be studied in individuals with AID, T2D, and healthy controls matched for cardiovascular risk factors. Advanced echocardiography and cardiovascular magnetic resonance will allow high-quality assessment of the different components of DHD (such as cardiac geometry, performance, and contraction). To identify the determinants of DHD, cardiac study results will be correlated with autonomic dysfunction tests, markers of small fiber neuropathy, and laboratory assessments of metabolic alterations, cardiac autoimmunity, and the inflammasome. Furthermore, genetic susceptibility to autoimmune diabetes and pancreatic autoimmunity will also be evaluated and correlated with DHD
Key Details
Gender
All
Age Range
30 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-06-20
Completion Date
2029-03
Last Updated
2026-11-02
Healthy Volunteers
Yes
Conditions
Interventions
Cardiac Magnetic Resonance
Cardiac Magnetic Resonance is an imaging technique for the assessment of the function and structure of the CV system, with high accuracy and reproducibility. Further, CMR enables to non-invasively evaluate coronary microvascular circulation and tissue characterizing the myocardium
Locations (1)
Policlinico Umberto I
Rome, Roma, Italy