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Relationship Between Insulin Dose and Complications in Type 1 Diabetes
Sponsor: Rachel Miller
Summary
The goal of this observational study is to better understand how the amount of insulin people with type 1 diabetes are using relates to blood glucose control and the risk of complications. The main questions this study aims to answer are: 1) Is insulin dose related to the long-term risk of developing heart disease, kidney disease and other complications in people with type 1 diabetes, after accounting for blood glucose? and 2) Does insulin dose relate to early signs of heart and kidney disease (i.e., disease that is not clinically detectable) in people with type 1 diabetes who are using modern diabetes management regimens?
Official title: Insulin Dose and Vascular Complications in Type 1 Diabetes: Its Role Beyond Insulin Resistance and Glycemia
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2027-01
Completion Date
2029-06
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
Routine/prescribed exogenous insulin dose
Aim 1: Participants will be observed under their self-reported, routine, physician-directed insulin doses using existing historical data since 1986-88. Aim 2: Data on routine, physician-directed insulin dose over the past 2 weeks will be downloaded from insulin delivery devices (pumps, smart pens). Participants not using such devices will complete manual insulin dose log sheets for 2 weeks.
Locations (1)
University of Pittsburgh
Pittsburgh, Pennsylvania, United States