Comparing Dextrose Prolotherapy vs. Sodium Hyaluronic Acid Injections for Jaw Joint Internal Derangement

NOT YET RECRUITING

NCT07911358

NA

Sponsor: Allama Iqbal Medical College

Summary

This is a randomized comparative study to evaluate the effectiveness of two intra-articular injections for the management of Temporomandibular Joint (TMJ) internal derangement. The study compares Dextrose Prolotherapy (12.5%) versus Sodium Hyaluronic Acid. Sixty patients (30 per group) with clinically diagnosed TMJ internal derangement (Wilkes Stage II or III) who have not responded to conservative treatment will be enrolled. Participants will be randomly assigned to receive either a single 1ml intra-articular injection of Dextrose or Sodium Hyaluronic Acid into the superior joint space. The primary outcomes are the mean change in pain intensity (measured on a Visual Analogue Scale) and Maximum Inter-Incisal Opening (measured in millimeters) at baseline, 1 month, and 3 months post-injection.

Official title: A Randomized Comparative Study of Sodium Hyaluronic Acid and Dextrose Prolotherapy in Management of Temporomandibular Joint Internal Derangement

Key Details

Gender

All

Age Range

18 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2027-01-01

Completion Date

2028-03-25

Last Updated

2026-11-02

Healthy Volunteers

No

Conditions

Temporomandibular Joint Internal Derangement TMJ-ID TMPDS Disc Displacement Temporomandibular Joint Dysfunction Syndrome Temporomandibular Joint Disc Displacement Temporomandibular Joint Disorders

Interventions

DRUG

Dextrose Prolotherapy

12.5% Dextrose solution (0.5ml 25% dextrose + 0.5ml 2% lidocaine) injected into the superior joint space

DRUG

Sodium Hyaluronic Acid

1ml of high molecular weight, non-cross-linked Sodium Hyaluronate injected into the superior joint space.

Locations (1)

Jinnah Hospital Lahore

Lahore, Punjab Province, Pakistan

Clinical Research Directory