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Perioperative Dutasteride for Hemorrhage Control in Bipolar TURP Under Anticoagulation.
Sponsor: Mohamed Mahmoud Dogha
Summary
A prospective, randomized, double-blinded controlled trial to evaluate the efficacy of a 2-week preoperative and 2-week postoperative course of oral dutasteride (0.5 mg daily) in reducing perioperative blood loss, irrigation requirements, and catheterization time in patients on anticoagulant therapy undergoing bipolar TURP for benign prostatic hyperplasia (BPH).
Official title: Perioperative Dutasteride Effect on Perioperative Haemorrhage During Bipolar Transurethral Resection of the Prostate in Anticoagulated Patients.
Key Details
Gender
MALE
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
44
Start Date
2026-10-21
Completion Date
2027-05-15
Last Updated
2026-11-02
Healthy Volunteers
No
Conditions
Interventions
Dutasteride (0.5mg)
Dutasteride 0.5 mg oral capsule (brand name Avodart; 0.5 mg daily for 2 weeks pre-op and 2 weeks post-op)
Placebo
Identical physical appearance and dosing schedule matching the active drug arm (1 capsule daily for 2 weeks preoperatively, followed by Bipolar TURP, and continued for 2 weeks postoperatively).
Locations (1)
Mohamed Mahmoud Dogha
Al Fayyum, Egypt