Clinical Research Directory

Inclusion Criteria: * Healthy males or non-pregnant, non-lactating females aged 18 to 55 years inclusive * BMI of 25.0 to 35.0 kg/m2 inclusive and weight ≥50 kg Exclusion Criteria: * History of any clinically important disease or disorder * History or presence of clinically significant cardiovascular, renal, hepatic, dermatological, respiratory, neurological, psychiatric or GI disorder including a history of pancreatitis or gall stones * History of suicidal ideation or behaviour * Any clinically significant illness, medical/surgical procedure, or trauma within 4 weeks of dosing * History of severe allergy/hypersensitivity or ongoing allergy/hypersensitivity, or history of hypersensitivity to any component of the AZD6234 or AZD9550 drug products * Prior or planned bariatric surgery or placement of a weight loss device * Participants who do not have suitable veins for multiple venepunctures/cannulation * Skin disorder/condition or tattoos in the abdominal area of the proposed injection site which can interfere with study assessments * Clinically significant abnormal clinical chemistry, haematology, coagulation or urinalysis * Basal calcitonin level \> 50 ng/L * Any clinically significant abnormal findings in vital signs * Any clinically significant abnormalities on 12-lead ECG * HbA1c ≥6.5% (≥48 mmol/mol) * Evidence of renal impairment * Females who are pregnant or lactating * Participants who have received any IMP in the last 90 days prior to dosing * Participants who have previously received AZD9550 and/or AZD6234 * Treatment with prescription or non-prescription medication intended for weight loss within 3 months before screening * Treatment with a GLP-1-containing preparation within 3 months before screening * Treatment with an amylin analogue containing preparation within 30 days before screening * Treatment with medication for diabetes within 3 months before screening * Treatment with medication associated with significant weight gain in the 3 months before screening * Plasma donation within 3 months of screening or any blood donation/loss more than 500 mL within 3 months before screening * Use of any prescribed or non-prescribed medication including antacids, gastric pH modifying agents, analgesics, herbal remedies, vitamins and minerals within 2 weeks of dosing * Use of drugs or herbal medications with CYP3A4 enzyme-inducing properties within 3 weeks of dosing * Current smokers or known or suspected history of alcohol or drug abuse * Excessive intake of caffeine-containing drinks or food