Clinical Research Directory

Inclusion Criteria: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Voluntarily signs and dates the informed consent form (ICF) prior to any study-related procedures. * Male or female adults aged 25 to 65 years at the time of screening. * Presence of visible horizontal neck wrinkles, specifically graded as HNWS grade 1 to 3 (mild to moderate neck lines), confirmed on baseline imaging and clinical examination by the investigator. * Willingness and ability to comply with all study procedures, visit schedules, and photographic requirements for the duration of the study. Exclusion Criteria: * Prior Procedures. * Absolute Exclusion - History of any prior hyaluronic acid filler injection, or fat grafting in the neck area at any time in the past. * Temporary Exclusion - History of botulinum toxin or energy-based device (EBD) treatments (e.g., focused ultrasound, radiofrequency, lasers) in the neck area within 6 months prior to screening. * Female subjects who are pregnant or breastfeeding. * Presence of damaged skin (e.g., areas affected by inflammation or infection), active skin disease (e.g., contact derma s, eczema, psoriasis) or infection (bacterial, viral, fungal) in the treatment area. * History of allergic diseases, sarcoid granulomatous pathology, Osler's endocarditis, autoimmune disease (e.g., lupus, scleroderma, dermatomyosi s) or current use of immunosuppressive therapy. * Known hypersensitivity or allergy to the ingredients of the investigational device DOT PN (Rejuran S) * History of keloid forma on, or hypertrophic scarring. * Current use of anticoagulants (e.g., warfarin, heparin), an platelet agents (e.g., aspirin, clopidogrel), or NSAIDs that cannot be discon nued at least 7 days prior to injection, or a known history of bleeding disorders. * Any other condition that, in the opinion of the investigator, would make the subject unsuitable for the study or compromise the safety or validity of the study results.