Clinical Research Directory

Inclusion Criteria: 1. Healthy Non-Elderly Trial Participants (Age≥ 18 years and \<65 years)，Healthy Elderly Trial Participants（Age≥ 65 years ）; 2. Body Weight: Male≥50.0kg, Female≥45.0kg; 19.0 ≤BMI≤ 28.0; 3. From ICF signing to 3 months post-last dose: no conception plans (participant/partner), no sperm/egg donation, effective contraception for 3 months post-last dose; no unprotected sex within 2 weeks pre-dose.; Exclusion Criteria: 1. Allergy or Drug hypersensitivity; 2. Clinically significant Medical History; 3. History of anesthesia accident, history of serious adverse reactions of anesthesia, or family history of anesthesia accidents, or contraindications to general anesthesia; 4. Dyspnoea or suspected difficult airway, or predicting difficult endotracheal intubation; 5. History of bronchial asthma, chronic obstructive pulmonary disease, sleep apnea syndrome; 6. History of adrenal insufficiency or adrenal tumor or hereditary heme biosynthesis disorder or hereditary acute porphyria; 7. Physical examination, vital signs, 12-lead electrocardiogram, posterior-anterior chest radiograph, abdominal ultrasound examination, and abnormal laboratory test results； 8. Elderly group: SBP ≥160 mmHg and/or DBP ≥100 mmHg; non-elderly group: SBP ≥140 mmHg and/or DBP ≥90 mmHg ； 9. History of any surgery within 3 months; 10. History of any Medication within 14 days; 11. History of any clinical study within 3 months; 12. History of any vaccine within 1 month; 13. History of any drug abuse; 14. Needle sickness, Hematosickness; 15. Massive blood loss (\> 400 mL) in the past 3 months; 16. Female volunteers are pregnant or lactating; 17. Heavy smoker ( more than 5 cigarettes/day) within 3 months; 18. History of alcohol abuse,or heavy alcohol intake (more than 14 units a week) within 6 months; 19. Heavy caffeine intake; 20. History of grapefruit, xanthine-rich foods intake within 48 hours; 21. Positive alcohol test; 22. Positive nicotine test; 23. Positive drugs of abuse test result.