Comparison of IV Dexmedetomidine Versus Clonidine Versus no Alpha 2 Agonist on Emergency Delirium, PACU Length of Stay and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: a Prospective Observational Study

NOT YET RECRUITING

NCT07913308

Sponsor: Universitair Ziekenhuis Brussel

Summary

Emergence delirium (ED) is a frequent complication in children undergoing general anesthesia, particularly following ENT procedures such as adenotonsillectomy. Alpha-2 adrenergic agonists, such as clonidine and dexmedetomidine, are commonly used in pediatric anesthesia for their sedative, analgesic, and ED-reducing properties.The purpose of this prospective observational study (CLONIDEX) is to evaluate and compare the occurrence of emergence delirium, Post-Anesthesia Care Unit (PACU) length of stay, and overall time to hospital discharge in pediatric patients undergoing (adeno)tonsillectomy with or without placement of myringotomy tubes who receive intravenous dexmedetomidine, intravenous clonidine, or no alpha-2 agonist as part of their standard anesthetic care.

Official title: Comparison of Intravenously Administered Dexmedetomidine Versus Clonidine Versus No Alpha-2 Agonist on Emergence Delirium, PACU Length of Stay, and Time to Hospital Discharge in Children Undergoing (Adeno)Tonsillectomy: A Prospective Observational Study

Key Details

Gender

All

Age Range

2 Years - 12 Years

Study Type

OBSERVATIONAL

Enrollment

150

Start Date

2026-12-01

Completion Date

2027-05-31

Last Updated

2026-11-03

Healthy Volunteers

No

Conditions

Emergency Delirium Postoperative Delirium (POD)Adenotonsillectomy Tonsillectomy Postoperative Pain Pediatric Anesthesia Complications Length of Stay Post Anesthesia Care Unit Length of Stay

Interventions

DRUG

Intravenous dexmedetomidine

Standard of care intraoperative intravenous administration of dexmedetomidine. Dose, timing, and administration are determined solely by the attending anesthesiologist.

DRUG

Intravenous clonidine

Standard of care intraoperative intravenous administration of clonidine. Dose, timing, and administration are determined solely by the attending anesthesiologist.

OTHER

Standard Anesthetic Care Without Alpha-2 Agonist

Standard anesthetic care during pediatric (adeno)tonsillectomy without administration of intraoperative alpha-2 adrenergic agonists.

Locations (1)

Universitair Ziekenhuis Brussel

Jette, Brussels Capital, Belgium

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