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The Effect of Liraglutide on Body Weight, Body Composition, Ectopic Lipid Accumulation and Insulin Sensitivity in Subjects With Overweight or Obesity Without Diabetes
Sponsor: Medical University of Bialystok
Summary
The aim of the study is to evaluate the effect of a 12-week liraglutide treatment as an addition to dietary intervention in comparison to dietary intervention alone on body weight, body composition, ectopic lipid accumulation and insulin sensitivity in subjects with overweight or obesity.
Official title: The Effect of Liraglutide as an Adjunct to Dietary Intervention on Body Weight, Body Composition, Ectopic Lipid Accumulation and Insulin Sensitivity in Subjects With Overweight or Obesity Without Diabetes
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
83
Start Date
2023-04-05
Completion Date
2026-01-19
Last Updated
2026-11-03
Healthy Volunteers
No
Conditions
Interventions
liraglutide
Liraglutide dosing: * Week 1: 0.6 mg once daily * Week 2: 1.2 mg once daily * Weeks 3-12: 1.8 mg once daily
Low-calorie diet with dietician's monitoring
Low glycemic index diet with a deficit of 500 kcal/day in relation to the participant's individual total daily energy expenditure. The nutrient goals for the diet are established at 45% energy from carbohydrates, 30% from fat, and 25% from protein. All participants will receive detailed guidelines and personalized menus for each day of the intervention before the start and every 4 weeks during the intervention.
Locations (1)
Medical University of Bialystok
Bialystok, Podlaskie Voivodeship, Poland